Lodhran is located on the northern side of river satluj. On its north are the districts of Multan, Khanewal and Vehari while Bahawalpur is on its southern side. On the east lies the districts of Vehari and Bahawalpur; while district Multan lies on the western side. District Lodhran is spread over an area of 1,790 square kilometres comprising of following three tehsils Lodhran, Dunyapur and Kahror Pakka.

The climate of the district is hot and dry in summer and cold in winter. The maximum and minimum temperature ranges between 42ºC and 28ºC in summer. During winter, the temperature fluctuates between 21ºC and 5ºC. The entire district is smooth plain. The sub-soil water in Dunyapur sub-division is brackish, while that in Kahror Pakka and Lodhran sub-divisions is sweet. The average rainfall in the district is 71mm.